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Publications

Here are the publications related to the EMBION facility

June 19, 2025

Impact of abiotic stress on miRNA profiles in tomato-derived extracellular vesicles and their biological activity.

Huang Z, Pych E, Whitehead BJ, Nejsum PL, Bellini I, Drace T, Boesen T, Paponov I, Rasmussen MK

June 6, 2025

Roles of dimeric intermediates in RNA-catalyzed rolling circle synthesis.

Kristoffersen EL, McRae EKS, Sørensen NR, Holliger P, Andersen ES

June 5, 2025

Three cryo-EM structures of CD109 reveal its mechanism of protease inhibition.

Almeida AV, Jensen KT, Harwood SL, Jørgensen MH, Nielsen NS, Thøgersen IB, Enghild JJ, Andersen GR

April 1, 2025

Comparison of cable bacteria genera reveals details of their conduction machinery.

Digel L, Justesen ML, Madsen NS, Fransaert N, Wouters K, Bonné R, Plum-Jensen LE, Marshall IPG, Jensen PB, Nicolas-Asselineau L, Drace T, Bøggild A, Hansen JL, Schramm A, Bøjesen ED, Nielsen LP, Manca JV, Boesen T

January 8, 2025

Structural basis of THC analog activity at the Cannabinoid 1 receptor.

Thorsen TS, Kulkarni Y, Sykes DA, Bøggild A, Drace T, Hompluem P, Iliopoulos-Tsoutsouvas C, Nikas SP, Daver H, Makriyannis A, Nissen P, Gajhede M, Veprintsev DB, Boesen T, Kastrup JS, Gloriam DE

December 30, 2024

The Cryo-EM structure of human CD163 bound to haptoglobin-hemoglobin reveals molecular mechanisms of hemoglobin scavenging.

Etzerodt A, Mikkelsen JH, Torvund-Jensen M, Hennig D, Boesen T, Graversen JH, Moestrup SK, Kollman JM, Andersen CBF

October 15, 2024

Conserved N-terminal Regulation of the ACA8 Calcium Pump with Two Calmodulin Binding Sites.

Larsen ST, Dannersø JK, Nielsen CJF, Poulsen LR, Palmgren M, Nissen P

October 2, 2024

Gal-3 blocks the binding between PD-1 and pembrolizumab.

Greisen SR, Bendix M, Nielsen MA, Pedersen K, Jensen NH, Hvid M, Mikkelsen JH, Drace T, Boesen T, Steiniche T, Schmidt H, Deleuran B

August 13, 2024

Structure of biofilm-forming functional amyloid PSMα1 from Staphylococcus aureus.

Hansen KH, Byeon CH, Liu Q, Drace T, Boesen T, Conway JF, Andreasen M, Akbey Ü

July 15, 2024

Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.

Pedersen CN, Yang F, Ita S, Xu Y, Akunuri R, Trampari S, Neumann CMT, Desdorf LM, Schiøtt B, Salvino JM, Mortensen OV, Nissen P, Shahsavar A

July 1, 2024

Zinc mediates control of nitrogen fixation via transcription factor filamentation.

Lin J, Bjørk PK, Kolte MV, Poulsen E, Dedic E, Drace T, Andersen SU, Nadzieja M, Liu H, Castillo-Michel H, Escudero V, González-Guerrero M, Boesen T, Pedersen JS, Stougaard J, Andersen KR, Reid D

May 21, 2024

Structural basis of Δ(9)-THC analog activity at the Cannabinoid 1 receptor.

Gloriam D, Thorsen T, Kulkarni Y, Sykes D, Bøggild A, Drace T, Hompluem P, Iliopoulos-Tsoutsouvas C, Nikas S, Daver H, Makriyannis A, Nissen P, Gajhede M, Veprintsev D, Boesen T, Kastrup J

April 9, 2024

Conformational changes in the Niemann-Pick type C1 protein NCR1 drive sterol translocation.

Frain KM, Dedic E, Nel L, Bohush A, Olesen E, Thaysen K, Wüstner D, Stokes DL, Pedersen BP

April 1, 2024

Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.

Bay Y, Venskutonytė R, Frantsen SM, Thorsen TS, Musgaard M, Frydenvang K, Francotte P, Pirotte B, Biggin PC, Kristensen AS, Boesen T, Pickering DS, Gajhede M, Kastrup JS

March 25, 2024

The reproduction process of Gram-positive protocells.

Kanaparthi D, Lampe M, Krohn JH, Zhu B, Hildebrand F, Boesen T, Klingl A, Phapale P, Lueders T

March 22, 2024

An RNA origami robot that traps and releases a fluorescent aptamer.

Vallina NS, McRae EKS, Geary C, Andersen ES

January 16, 2024

Cryo-EM structure and functional landscape of an RNA polymerase ribozyme.

McRae EKS, Wan CJK, Kristoffersen EL, Hansen K, Gianni E, Gallego I, Curran JF, Attwater J, Holliger P, Andersen ES

December 1, 2023

RNA target highlights in CASP15: Evaluation of predicted models by structure providers.

Kretsch RC, Andersen ES, Bujnicki JM, Chiu W, Das R, Luo B, Masquida B, McRae EKS, Schroeder GM, Su Z, Wedekind JE, Xu L, Zhang K, Zheludev IN, Moult J, Kryshtafovych A

November 18, 2023

Activation and substrate specificity of the human P4-ATPase ATP8B1.

Dieudonné T, Kümmerer F, Laursen MJ, Stock C, Flygaard RK, Khalid S, Lenoir G, Lyons JA, Lindorff-Larsen K, Nissen P

August 1, 2023

T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy.

Hansen AS, Jensen LS, Gammelgaard KR, Ryttersgaard KG, Krapp C, Just J, Jønsson KL, Jensen PB, Boesen T, Johansen M, Etzerodt A, Deleuran BW, Jakobsen MR

August 1, 2023

T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy.

Hansen AS, Jensen LS, Gammelgaard KR, Ryttersgaard KG, Krapp C, Just J, Jønsson KL, Jensen PB, Boesen T, Johansen M, Etzerodt A, Deleuran BW, Jakobsen MR

August 1, 2023

T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy.

Hansen AS, Jensen LS, Gammelgaard KR, Ryttersgaard KG, Krapp C, Just J, Jønsson KL, Jensen PB, Boesen T, Johansen M, Etzerodt A, Deleuran BW, Jakobsen MR

July 1, 2023

Structure, folding and flexibility of co-transcriptional RNA origami.

McRae EKS, Rasmussen HØ, Liu J, Bøggild A, Nguyen MTA, Sampedro Vallina N, Boesen T, Pedersen JS, Ren G, Geary C, Andersen ES

May 22, 2023

RNA origami scaffolds facilitate cryo-EM characterization of a Broccoli-Pepper aptamer FRET pair.

Sampedro Vallina N, McRae EKS, Hansen BK, Boussebayle A, Andersen ES

May 20, 2023

Tertiary structure of single-instant RNA molecule reveals folding landscape.

Liu J, McRae EKS, Zhang M, Geary C, Andersen ES, Ren G

February 22, 2023

Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.

Amstrup SK, Ong SC, Sofos N, Karlsen JL, Skjerning RB, Boesen T, Enghild JJ, Hove-Jensen B, Brodersen DE

January 1, 2023

Sarkosyl differentially solubilizes patient-derived alpha-synuclein fibril strains.

Gram H, Theologidis V, Boesen T, Jensen PH

December 1, 2022

Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity.

Neumann C, Rosenbaek LL, Flygaard RK, Habeck M, Karlsen JL, Wang Y, Lindorff-Larsen K, Gad HH, Hartmann R, Lyons JA, Fenton RA, Nissen P

October 18, 2022

Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.

Kobberø SD, Gajhede M, Mirza OA, Kløverpris S, Kjær TR, Mikkelsen JH, Boesen T, Oxvig C

October 18, 2022

Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.

Kobberø SD, Gajhede M, Mirza OA, Kløverpris S, Kjær TR, Mikkelsen JH, Boesen T, Oxvig C

September 1, 2022

Structures and mechanism of the plant PIN-FORMED auxin transporter.

Ung KL, Winkler M, Schulz L, Kolb M, Janacek DP, Dedic E, Stokes DL, Hammes UZ, Pedersen BP

May 31, 2022

Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.

Nielsen NS, Zarantonello A, Harwood SL, Jensen KT, Kjøge K, Thøgersen IB, Schauser L, Karlsen JL, Andersen GR, Enghild JJ

April 13, 2022

Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders.

Dieudonné T, Herrera SA, Laursen MJ, Lejeune M, Stock C, Slimani K, Jaxel C, Lyons JA, Montigny C, Pomorski TG, Nissen P, Lenoir G

March 15, 2022

Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.

Nielsen J, Brandt J, Boesen T, Hummelshøj T, Slaaby R, Schluckebier G, Nissen P

January 5, 2022

High-resolution structure of native toxin A from Clostridioides difficile.

Aminzadeh A, Larsen CE, Boesen T, Jørgensen R

August 6, 2021

Structural Basis of Substrate-Independent Phosphorylation in a P4-ATPase Lipid Flippase.

Timcenko M, Dieudonné T, Montigny C, Boesen T, Lyons JA, Lenoir G, Nissen P

February 1, 2021

Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2.

Krintel C, Dorosz J, Larsen AH, Thorsen TS, Venskutonytė R, Mirza O, Gajhede M, Boesen T, Kastrup JS

August 25, 2020

Tracing the In Vivo Fate of Nanoparticles with a "Non-Self" Biological Identity.

Mohammad-Beigi H, Scavenius C, Jensen PB, Kjaer-Sorensen K, Oxvig C, Boesen T, Enghild JJ, Sutherland DS, Hayashi Y

July 1, 2020

Polymer-Lipid Hybrid Vesicles and Their Interaction with HepG2 Cells.

Brodszkij E, Westensee IN, Bertelsen M, Gal N, Boesen T, Städler B

June 19, 2020

DNA flowerstructure co-localizes with human pathogens in infected macrophages.

Franch O, Gutiérrez-Corbo C, Domínguez-Asenjo B, Boesen T, Jensen PB, Nejsum LN, Keller JG, Nielsen SP, Singh PR, Jha RK, Nagaraja V, Balaña-Fouce R, Ho YP, Reguera RM, Knudsen BR

March 13, 2020

Carbon dots-fed Shewanella oneidensis MR-1 for bioelectricity enhancement.

Yang C, Aslan H, Zhang P, Zhu S, Xiao Y, Chen L, Khan N, Boesen T, Wang Y, Liu Y, Wang L, Sun Y, Feng Y, Besenbacher F, Zhao F, Yu M

March 9, 2020

Full-length human GLP-1 receptor structure without orthosteric ligands.

Wu F, Yang L, Hang K, Laursen M, Wu L, Han GW, Ren Q, Roed NK, Lin G, Hanson MA, Jiang H, Wang MW, Reedtz-Runge S, Song G, Stevens RC

February 25, 2020

Differential Nanoparticle Sequestration by Macrophages and Scavenger Endothelial Cells Visualized in Vivo in Real-Time and at Ultrastructural Resolution.

Hayashi Y, Takamiya M, Jensen PB, Ojea-Jiménez I, Claude H, Antony C, Kjaer-Sorensen K, Grabher C, Boesen T, Gilliland D, Oxvig C, Strähle U, Weiss C

July 1, 2019

Namdinator - automatic molecular dynamics flexible fitting of structural models into cryo-EM and crystallography experimental maps.

Kidmose RT, Juhl J, Nissen P, Boesen T, Karlsen JL, Pedersen BP

July 1, 2019

Structure and autoregulation of a P4-ATPase lipid flippase.

Timcenko M, Lyons JA, Januliene D, Ulstrup JJ, Dieudonné T, Montigny C, Ash MR, Karlsen JL, Boesen T, Kühlbrandt W, Lenoir G, Moeller A, Nissen P

March 11, 2019

Molecular architecture of the Jumonji C family histone demethylase KDM5B.

Dorosz J, Kristensen LH, Aduri NG, Mirza O, Lousen R, Bucciarelli S, Mehta V, Sellés-Baiget S, Solbak SMØ, Bach A, Mesa P, Hernandez PA, Montoya G, Nguyen TTTN, Rand KD, Boesen T, Gajhede M

January 8, 2018

Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state.

Aduri NG, Ernst HA, Prabhala BK, Bhatt S, Boesen T, Gajhede M, Mirza O

January 1, 2018

Effect of Aerosolization and Drying on the Viability of Pseudomonas syringae Cells.

Alsved M, Holm S, Christiansen S, Smidt M, Rosati B, Ling M, Boesen T, Finster K, Bilde M, Löndahl J, Šantl-Temkiv T

January 1, 2018

The Cell Envelope Structure of Cable Bacteria.

Cornelissen R, Bøggild A, Thiruvallur Eachambadi R, Koning RI, Kremer A, Hidalgo-Martinez S, Zetsche EM, Damgaard LR, Bonné R, Drijkoningen J, Geelhoed JS, Boesen T, Boschker HTS, Valcke R, Nielsen LP, D'Haen J, Manca JV, Meysman FJR

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